The Center for Advanced Light Microscopy Osnabrück (CALMOS) is an imaging facility of the University of Osnabrück. Within the framework of the collaborative research center SFB 944 "Physiology and Dynamics of Cellular Microcompartments", CALMOS has gained profound expertise in applying super-resolution imaging to living cells. Furthermore, the SFB 944 initated the installation of an electron microscopy platform making state-of-the-art electron micoroscopy techniques accessible. Currently being an imaging facility with a decentralized infrastructure at the Department of Biology, CALMOS and the electron microscopy unit will be relocated into the Center of Cellular Nanoanalytics (CellNanOs) as an integrated bioimaging facility (iBIOS) in 2017.

CALMOS and the EM unit provide access to advanced flourescence and electron microscopy techniques with highest spatial and temporal resolution. With respect to light microscopy, the main research focus lies on single molecule based imaging (PALM/STORM) and single molecule tracking as well as single molecule spectroscopy (FLIM, FCS). Furthermore, CALMOS establishes cutting-edge techniques such as lattice light-sheet microscopy and developes new nanoparticle based methods such as upconversion microscopy and second harmonic generation microscopy in close collaboration with the biophysics group of Prof. Jacob Piehler. In electron microscopy, the EM unit establishes correlative light-electron microscopy (CLEM) approaches and 2D and 3D (cryo-)scanning and transmission electron microscopy techniques.

CALMOS and the EM unit use newest protein labeling techniques and probe the application of functionalized and biocompatible nanoparticles in living cells as well as for CLEM.

Please, contact us to discuss if your project can be conducted at our imaging systems.